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DXL Calscan Study Summary


DXL Calscan- a clinically proven diagnostic tool
With over 30 clinical studies published in leading scientific journals around the world, Calscan is a clinically proven tool for any health care center or private physician office. In a hospital environment, Calscan can be used as a stand-alone tool or as an effective complement to an axial DXA device.
Many clinicians wonder about the correlation between DXL, DXA and ultrasound. On the graph shown to the right, you can see the reference curves of healthy individuals scanned using DXL Calscan compared to DXA femur neck (NHANES III), DXA spine, DXA total hip, heel ultrasound and forearm DXA. The International Society of Clinical Densitometry recommends that the NHANES III database be used for hip scans worldwide and the femur neck region should be used. Looking at the graph, you can see how well Calscan results correlate to this database. Ultrasound and total hip results are less sensitive to differences in bone density while forearm scans are less reliable on the elderly due to changes in the shape of the radius with advancing age.
Given the scale of the potential for error associated with traditional DXA scans of the hip and spine (as mentioned in the “Accuracy” section of this website), any perceived advantages of scanning on the hip and spine are negated. The focus of the clinician should be to help more patients prevent fragility fractures rather than time-consuming training to reduce operator and device errors.
The following quotes about the clinical performance of DXL Calscan are taken from published clinical studies:
“The age-adjusted AUC of DXL of calcaneus to predict future hip fractures was 0.84, which is better than that previously reported for DXA of the femoral neck. Of the patients who sustained a hip fracture, 78% had a DXL T-score of <-2.5. DXL of calcaneus may therefore be suitable for diagnosing osteoporosis and for prediction of fracture risk.”
Brismar TB, Janszky I, Toft LIM; Journal of Osteoporosis vol 2010, Art ID 875647, 6 pages.
“Scans of the calcaneus by DXL Calscan show an ability to identify vertebral fracture patients that is superior to DXA results obtained from the same patient database using the iDXA device in accordance with the WHO recommendations.”
Muschitz C, Laimer M, Resch H, Journal Miner Stoffwechs 2008:15
“The Calscan is well suited for use in the management of post-menopausal osteoporosis.”
Thorpe, J.A., Steel, S.A., The British Journal of Radiology, 79 (2006), 336–341
“DXL Calscan provides a more accurate measure of calcaneal BMD than traditional DXA instruments.”
Hakulinen M., Saarakkala S., et al, Physics in Medicine and Biology 48 (2003) 1741-1752.)
“We conclude that DXL measurement at the heel bone, using a T-score threshold of –2.5 for classification of osteoporosis, is in concordance with the World Health Organization (WHO) definition of osteoporosis.”
Kullenberg R., Falch J. Osteoporosis International (2003) 14: 823-827
“We conclude that BMD values obtained with DXA and DXL correlate well and that the DXA and DXL techniques effectively identify the same individuals with low BMD.”
Söderpalm AC, Kullenberg R, Swolin-Eide D, Journal of Clinical Dens., vol.11, no.4, (2008) p. 555-560.
DXL Calscan correlation to femur neck and spine 1,2
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1) Kullenberg R., Falch J. Prevalence of osteoporosis using bone mineral measurements at the calcaneus by dual X-ray and laser (DXL), Osteoporosis International (2003) 14: 823-827. /td>
2) Kullenberg R., Reference database for Dual X-ray and laser (DXL) Calscan bone densitometer, Journal of Clin. Dens, vol. 6 no.4, 367-371, 2003. /td>